Kantian's Skincare Technology

Kantian’s Skincare Technology is based on a multi-functional, topically applied, two-part aqueous composition. It has demonstrated an enhanced efficacy in the treatment of acne vulgaris and other skin afflictions. This unique system, based on a sequential combination of the two-part aqueous composition, creates a mixture of at least three beneficial acidic substances, as well as a beneficial gaseous substance. The beneficial acidic substances form a complex of powerful keratolytic and antimicrobial agents, whereby the component, multiple acid substances are serving either single or dual functions. Keratolysis is a loosening or separation of the horny layer of the epidermis. This process facilitates the release of sebum (the oily secretion of sebaceous glands) trapped in the pustules and papules on the skin of people afflicted with acne.
This two-part aqueous composition successfully accomplishes specific treatment objectives with each sequentially applied phase. The protocol consists of the initial application of an acidic phase, containing salicylic acid, a β-hydroxy acid (FDA approved for the treatment of acne vulgaris), which provides both keratolytic and antimicrobial activity; and mandelic acid, an α-hydroxy acid which significantly supplements both of these functions. This initial application is followed by application of an alkaline phase, containing a nitrite salt, which takes advantage of the residual acidity remaining on the skin to trigger a powerful antimicrobial species, specifically the nitrous acid component of the metastable [nitrite ⇌ nitrous acid] equilibrium. This germicidal environment has proven to be capable of destroying a broad spectrum of bacteria and fungi, including P acnes, the organism found in high numbers on acne sufferers’ skin. Additionally, the sequentially applied nature of the two-part aqueous composition allows each phase to work independently and optimally in terms of their respective keratolytic and antimicrobial capabilities, enabled by a 5-15 minute delay between each phase’s application.

Kantian’s proprietary skincare technology is based on a multi-functional, topically applied, two-part aqueous composition. This unique system, based on a sequential combination of the two-part aqueous composition, creates a mixture of at least three beneficial acidic substances, as well as a beneficial gas. The acidic substances form a complex of powerful keratolytic and antimicrobial agents, whereby the component acids serve either single or dual functions. Keratolysis is a loosening or separation of the horny layer of the epidermis. This process facilitates the release of sebum (the oily secretion of sebaceous glands) trapped in the pustules and papules on the skin of people afflicted with acne.


This two-part aqueous composition successfully accomplishes specific treatment objectives with each sequentially applied phase. The protocol consists of the initial application of an acidic phase, containing salicylic acid, a β-hydroxy acid that provides both keratolytic and antimicrobial activity, and mandelic acid, an α-hydroxy acid which significantly supplements both of these functions. This initial application is followed by the subsequent application of an alkaline phase that contains a nitrite salt, which in combination with the residual acidity remaining on the skin after application of the first phase, establishes a metastable [nitrite ⇌ nitrous acid] equilibrium, thus generating nitrous acid, a powerful antimicrobial species. This germicidal environment has proven to be capable of destroying a broad spectrum of bacteria, viruses and fungi, including Propionibacterium acnes, the organism found in high numbers on acne sufferers’ skin. Additionally, the sequentially applied nature of the two-part aqueous composition allows each phase to work independently and optimally in terms of their respective keratolytic and antimicrobial capabilities, enabled by a 5-15 minute delay between each phase’s application.


The desired pH of each phase independently (taking into account each acid’s pKa value, and the alkaline stability of nitrite), as well as the combined pH, have been carefully calculated in order to maximize the keratolytic and antimicrobial capabilities of salicylic and mandelic acids, and that of the subsequent nitrous acid, while minimizing the potential for irritation or discomfort. These calculations are significantly dependent on the relative amounts of the free acid form of each of the particular compounds in relation to its inactive salt form. For example, the pKa of salicylic acid is 2.97, which means that when salicylic acid is a component of an aqueous composition at a pH of about 3.0, roughly one-half of that compound will exist in the active keratolytic acid form and roughly one-half of that compound will exist in the inactive salt form. The same consideration of keratolytic activity vs. acid:salt forms applies as well to mandelic acid.


It should be noted that the U.S. Food & Drug Administration allows the sale of over-the-counter acne drugs under 21 C.F.R. Part 333, "Topical Acne Drug Products for Over-the-Counter Human Use". Under 37 C.F.R. §333.310, Acne active ingredients: (a) lists salicylic acid 0.5 to 2 percent. Salicylic acid, by its very nature as a keratolytic agent, has an inherent skin irritancy, as do all the other α-hydroxy acids to some degree. In developing an effective acne composition, it is important therefore to establish a pH for the formulation that provides a sufficient amount of salicylic acid in its unionized form to dissolve the skin tissue. The ionized salicylate form has no such activity. The pH for these compositions is of great significance. A pH should be chosen for both the acidic phase alone and the alkaline phase alone, as well as the pH of the resulting mixture, such that they individually are, and upon sequential application to the skin, of optimum efficacy, stability, and of minimum irritation potential.


Furthermore, several technical publications suggest that nitric oxide, a gaseous byproduct of the metastable [nitrite ⇌ nitrous acid] equilibrium, has the ability to penetrate skin tissue causing localized vasodilation. Vasodilation is well-known to be beneficial in terms of the skin’s ability to promote healing. In addition to promoting vasodilation, it has recently been demonstrated that low levels of nitric oxide cause bacterial biofilm dispersal in a variety of bacterial species. Bacterial biofilms are communities of bacteria living within a self-secreted matrix. Biofilm infections are typically difficult to treat because they are extremely resistant to traditional antibiotics. As P. acnes is likely living in a biofilm form on skin, nitric oxide generated by the acidified nitrite in this formulation could have several beneficial effects for fighting skin infections.  


Intellectual Property


1) US Patent # 9662341


2) US Patent # 8932650


3) US Patent # 9295681